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Blood: The Last Vampire is a 2000 anime film produced by Production I. G and SPE Visual Works and directed by Hiroyuki Kitakubo. The film premiered in theaters in Japan on November 18, 2000.
In Japan, the vampire-hunter Saya, who is a powerful original, is sent by her liaison with the government, David, posed as a teenage student to the Yokota High School on the eve of Halloween to hunt down vampires. Saya asks David to give a new katana to her. Soon she saves the school nurse Makiho Amano from two vampires disguised of classmates and Makiho witnesses her fight against the powerful demons.